Microsoft Biology Foundation

via http://mbf.codeplex.com/:

The Microsoft Biology Foundation (MBF) is a language-neutral bioinformatics toolkit built as an extension to the Microsoft .NET Framework, initially aimed at the area of Genomics research. Currently, it implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to biological web services such as NCBI BLAST. MBF is available under an open source license, and executables, source code, demo applications, and documentation are freely downloadable.
The source code and development of MBF is managed on this CodePlex site, but all downloads are hosted on the Microsoft Research site here:http://research.microsoft.com/bio/.

via http://research.microsoft.com/en-us/projects/bio/:

Tools available:

• Microsoft Biology Foundation
• The Microsoft Biology Foundation (MBF) is a language-neutral bioinformatics tool kit built as an extension to the Microsoft .NET Framework. It implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to biological web services such as the U.S. National Center for Biotechnology Information’s Basic Local Alignment Search Tool. MBF is available under an open-source license, and executables, source code, demo applications, and documentation are freely downloadable.
• ShoRuntime for MBF
• a library that delivers advanced math and graphing capabilities on the .NET platform
• Microsoft Biology Tools
• Microsoft Research Biology Extension for Excel
• Add-in that provides a simple, flexible way to work with genomic sequences, metadata, and interval data in an Excel workbook by exposing the features and functions of the Microsoft Biology Foundation.
• Microsoft Research Sequence Assembler
• Sequence Assembler is a proof-of-concept-application that demonstrates the use of the Microsoft Biology Foundation, the .NET Framework, the Windows Presentation Foundation, and Microsoft Silverlight for bioinformatics research. The MBF Sequence Assembler uses rich user interface elements to enable the visualization and manipulation of genomic data.

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Video tutorial given at the Microsoft eScience Workshop in 2009 at Carnegie-Mellon University: http://research.microsoft.com/en-us/um/redmond/events/escience2009/17961/lecture.htm. This tutorial is based on an early version of the code, but gives a good introduction and high-level overveiw of the architecture.